Single mother Christine Scavello turns to private detective Charlie Harrison for help when her young son Joey becomes the target of a fanatical religious group that believes the child to be the Antichrist.
When the Antichrist takes over the world, Rayford, Buck, Bruce, and Chloe form the Tribulation Force to try and stop the war, famine, plagues, and disasters that are killing millions of people.
Rayford Steele and the rest of the Tribulation Force having been left behind when the prophesied Rapture took believers to heaven, are now involved in a mission to win as many people as possible to Jesus while at the same time dealing with Nicolae Carpathia, the man they suspect is the Antichrist.