Ten-year-old inventor Andrew Dubble decides to test his latest creation, the Atom Sucker, and accidentally shrinks himself, his robot Thudd, and his cousin Judy down to the size of specks--unfortunately lodged near the nose of the neighbor's dog.
Mia and Michael Battelli have been begging their reluctant parents for a pet, so when Mia finds Callie, an injured stray, foraging for food, she takes her home, hoping her parents will allow the tiny cat to stay.
To escape an abusive master, a junkyard dog named Flats runs away and makes a name for himself from Mississippi to New York City playing blues on his guitar.