Spider-Man travels to Florida to battle the Lizard, a half-man, half-alligator, but after learning the story of how the creature came into existence, he decides a different type of help is needed.
Peter Parker, discouraged that Spider-Man was unable to defeat Dr. Octopus in their first meeting, is inspired by a speech from the Human Torch to try again to subdue the madman.
Spider-Man takes up photography in order to make extra money to pay the rent, and is able to bring the Vulture to justice, as well as uncover an alien plot to destroy the world.
A new villain has been terrorizing New York City. He strikes soundlessly from the air and he strikes with no warning. Peter tries to get pictures of The Vulture for Jamison Publications, and uses his spider powers to do it.
Spider-Man battles against menacing villains such as the Vulture, the Tinkerer, Doctor Octopus, the Sandman, Doctor Doom and the Lizard in six action filled short stories.