With the Redface Pox running rampant and no male heir to the shogunate, despite Iemitsu and Arikoto's best efforts, it is becoming obvious that Japan must break from its centuries-old traditions if the country is to have a future.
When a strange disease called the Red Pox preys on the men of Edo-period Japan, the male population falls drastically, causing women to take on traditional male roles, including that of Shogun, to whom the most beautiful men are sent to serve.