A man who was once mentally retarded must face his gradual return to his former state when the astounding results of an experimental surgery that increased his intelligence prove only temporary.
The story of Charlie, a gentle mentally-handicapped man, the repercussions he faces after undergoing brain surgery, and the unbreakable bond he has with a lab mouse, Algernon.
After Charlie, a mentally handicapped man, agrees to have an experimental surgery that could reduce his handicap and increase his intelligence, Charlie discovers that happiness and abilities aren't necessarily connected.