Although Aunt Arlene tries to interest her in clothing and growing up, ten-year-old Mildred is entirely focused on growing a pumpkin big enough to win the annual Circleville, Ohio, contest, as her mother dreamed of doing before she died.
Determined not to be weird all his life like his neighbor, Charley Maplewood decides to throw himself a tenth birthday party, complete with a "house of horrors" theme, but first he will have to make some friends to invite.
To the constant disappointment of his mother and his teachers, Joey has trouble paying attention or controlling his mood swings when his prescription medications wear off and he starts getting worked up and acting wired.
Nine-year-old Lenny gets in trouble and has no friends because he cannot control himself in school and his interests are not like those of his classmates, until he starts visiting Muriel, a counselor, and meets Van, a boy his age who has leukemia.
When he is assigned Teddy Roosevelt as his biography project in school, fourth-grader Riley finds himself inspired by Roosevelt's tenacity and perseverance and resolves to find a way to get what he most wants--a saxophone and music lessons.
With their mother dead and their father working nights, Retta tries to be mother to her two younger brothers but somehow things just don't seem to be working right.