When Kirby, Bitsy, and their parents inherit an unusual and very pink motel in Florida, they find it filled with eccentric characters, mystery, and adventure.
While Rumble the dragon and his staff argue with the leader of the orchestra Rumble hired about whether the violinist, a snake, can come into the hotel, she slithers in, eats some porridge, and falls asleep in a just-right bed.
In 1987, while her mother sits in a Baltimore hotel at the deathbed of a grandmother twelve-year-old Annie never knew, Annie travels back fifty years and shares adventures with the lonely girl who will grow up to be her feisty grandmother.
When a thunderstorm forces the Mystery, Inc., crew to stop at the "Creepy Motel" overnight, Scooby-Doo and Shaggy have to contend with a room filled with ghosts and a television that only shows scary movies.