While on a mission to prove to Merlin that they can use magic wisely, Jack and Annie travel to seventeenth-century Venice, Italy, to save the city from disaster.
Eight-year-old Jack and his younger sister Annie use the magic tree house to travel back to the Middle Ages, where they explore a castle and are helped by a mysterious knight.
Their magic tree house takes Annie and Jack to Pompeii just as Vesuvius is about to erupt, and they must find a Roman scroll before everything is covered with burning ash.
When Jack and Annie travel back to the Kansas prairie in search of "something to learn," they gain an understanding of how hard life was for pioneers and they experience the terror of a tornado.
Jack and Annie travel in their magic treehouse to the year 1621, where they celebrate the first Thanksgiving with the Pilgrims and Wampanoag Indians in the New Plymouth Colony.
The magic tree house transports Jack and Annie on a mission to the Ice Age where they encounter Cro-Magnons, cave bears, sabertooth tigers, and woolly mammoths.
Jack and Annie travel in their magic tree house to Elizabethan London, where they become actors in a production of A Midsummer Night's Dream and try to rescue a tame bear.
Using their magic tree house, Jack and Annie travel back to the time of the American Revolution and help General George Washington during his famous crossing of the Delaware River.