After the death of the beloved aunt who has raised her, twelve-year-old Summer and her uncle Ob leave their West Virginia trailer in search of the strength to go on living.
Great-aunt Alice Rumphius was once a little girl who loved the sea, longed to visit faraway places, and wished to do something to make the world more beautiful.
Although Aunt Arlene tries to interest her in clothing and growing up, ten-year-old Mildred is entirely focused on growing a pumpkin big enough to win the annual Circleville, Ohio, contest, as her mother dreamed of doing before she died.
Although Lolly loves to visit her Auntie Zep's house, she feels homesick when she actually gets there, and so Auntie Zep retrieves the Secret Remedy Book from an old trunk.
Eccentric Aunt Sally comes from Canada to babysit the Anderson children while their parents are on a trip to Paris and every night the bedtime story adds another piece to a very suspect family history.
Josefina and her sisters distrust learning to read and write, as well as other changes their T?a Dolores is bringing to the household, because they fear they will lose their memories of their mother.