Victor Helios (formerly Frankenstein) has continued his work and again has discovered the danger in creating life. He cannot stop the engineered killers he has set loose in modern New Orleans. Only his first "monster" and his two human partners have a chance to end the destruction.
A hurricane and the deadly creations of Victor Helios threaten the future of New Orleans and the only hope lies with Victor's first failed attempt to build the perfect human. After they face off with an indestructible entity, the damned creature and his mad creator will confront each other.
Detective Carson O'Connor and her partner Michael Maddison investigate a series of murders. She begins to suspect that the killer has actually crossed the ages and that they must find not only him but his maker.
Edna Pontellier, a Victorian-era wife and mother, is awakened to the full force of her desire for love and freedom when she becomes enamored with Robert LeBrun, a young man she meets while on vacation.
C?cile Rey, spending the summer volunteering with her friend Marie-Grace Gardner at a nearby orphanage, forms a special bond with a young girl named Perrine and decides to try and raise money for the children by helping in a huge benefit.
Sonny's mother loses her job in New Orleans during the Depression, but Smilin' Jack, a jazz musician, explains to Sonny how he can organize a rent party to raise the money they need.
Details the experiences of Abdulrahman Zeitoun, a Syrian-American and New Orleans resident, and his family, in the aftermath of Hurricane Katrina, and describes how he was arrested and falsely imprisoned because of his ethnicity.
Celeste, a mouse longing for a real home, becomes a source of inspiration to teenaged Joseph, assistant to the artist and naturalist John James Audubon, at a New Orleans, Louisiana, plantation in 1821.