Having recovered their human shape, Emeralda and Eadric try to help Aunt Grassina find the special objects needed to break the spell that turned Grassina's true love, Haywood, into an otter.
Middle-schooler Isabelle Bean follows a mouse's squeak into a closet and falls into a parallel universe where the children believe she is the witch they have feared for years, finally come to devour them.
Strega Nona tries to teach Big Anthony about gardening and the importance of order, but when Anthony does not follow her directions and uses her growing spell, his small vegetable patch turns into an uncontrollable jungle.
Through an heirloom music box, Leo, a serious, responsible boy, and his badly-behaved cousin Mimi enter the magical world of Rondo to rescue Mimi's dog from a sorceress, who wishes to exchange him for the key that allows free travel between worlds.