Third grader Judy Moody is in a first day of school bad mood until she gets an assignment to create a collage all about herself and begins creating her masterpiece, the Me collage.
Stink Moody, friends Webster and Sophie, and Mrs. Birdwistle visit tourist attractions in Virginia as they try to give away 101 guinea pigs rescued from a laboratory, although Stink is very reluctant to relinquish his favorite, Astro.
A class visit to the Gross-Me-Out exhibit at the science museum inspires Stink Moody to create a variety of terrible smells to put on the sneakers he plans to enter in the World's Worst Super-Stinky Sneaker contest.
Julie Albright, forced to move with her mom following her parents' divorce, is excited to learn her new school has a basketball team; but when the coach says girls are not allowed on the team, she jeopardizes her chances for making new friends by deciding to fight for her right to play.
The shortest kid in the second grade, James Moody, also known as Stink, learns all about the shortest president of the United States, James Madison, when they celebrate Presidents' Day at school.