A clash with The Punisher lands the Runaways in New York in 1907, where the teens must deal with child labor, quaint technology, and competing gangs of superfolk called "Wonders" as they search for a way back.
Once the evil Pride is gone from Los Angeles, every villain in the Marvel Universe is looking to fill the void and it is up to the Runaways to stop them. Then, a new team of young superheroes shows interest in the Runaways.
The Runaways welcome a stranger into their midst, only to learn he harbors a shocking secret that endangers them all. Then, the young mutants have an encounter with crimefighters Cloak and Dagger, once teenage runaways themselves, who have been sent to catch them.
A group of six young mutants, having discovered their parents are all secretly super-powered villains, run away from home and embark on a series of adventures, fueled by their desire to thwart their legacy of evil.
Peter Parker has even more trouble balancing his personal and his superhero lives when shamed scientist Otto Octavius takes to the streets as the rampaging Dr. Octopus and the Amazing Spider-Man must first stop the destruction, then prevent a nuclear device from destroying New York City.
Back in Los Angeles, the Runaways face their biggest challenge to date when soldiers from Karolina Dean's home planet arrive and demand the surrender of their fellow Majesdanians for an unnamed crime, and the juvenile superheroes are at odds over how to respond to the threat.
A group of six young mutants, having discovered their parents are all secretly super-powered villains, run away from home and embark on a series of adventures, fueled by their desire to thwart their legacy of evil.