Dr. John Stapleton, embittered by the deaths of his wife and daughters in a plane crash and the loss of his ophthalmology practice to AmeriCare, retrains for a career in forensic pathology where he uncovers a plot by the health care giant to kill off its more costly subscribers.
Dr. Cassandra Kingsley is investigating sudden surgical deaths at Boston Memorial Hospital and her husband, a top surgeon, seems headed for a breakdown. Cassi is admitted to the hospital for an eye operation and she becomes the "Godplayer's" next target.
In late eighteenth-century Northumberland, England, sixteen-year-old Jessamine Luxton is so desperate to find Weed, who her father says deserted her when she was at death's door, that she asks for help from the evil Oleander.