Nancy Drew and Frank and Joe Hardy find another mystery while vacationing in Italy, where they help an American girl with no memory discover the truth about how she got to Rome and why someone wants to hurt her.
On a trip to London, Nancy thinks she is running a simple errand when she checks on a Shakespeare professor's home while he is away, but things get complicated when she discovers an eerily empty living room and her father disappears soon after.
Nancy Drew must juggle acting and sleuthing when a suspicious fire breaks out on the set of a historical film about River Heights in which she is starring.