At the opening of a new toy store, Curious George makes a mess and gets into trouble, but the owner soon sees that things aren't as bad as they appear.
Away from his ordinary life in 1899 Maine, Basil Pepperell travels to forbidden Monkey Island--a floating scientific laboratory where evil Dr. Von Rottweil plans to use an advanced society of monkeys to further his plan of "Peace Through World Domination.".
A small boy with a desire to own a candy shop meets a window-washing team of a giraffe, a pelican, and a monkey and together they go to work for the wealthy Duke of Hampshire, who makes all their dreams come true.