FBI agent Clarice Starling's involvement in a dramatic drug bust brings her once again to the attention of cannibal killer Dr. Hannibal Lecter who escaped from custody seven years earlier after helping Clarice nab a serial murderer.
A young F.B.I. trainee interviews a brilliant psychiatrist and killer in the hopes of tracking down a serial killer with the grotesquely apt nickname--Buffalo Bill--who is stalking particular women.