At a boarding school in Switzerland, fourteen-year-old Alex Van Helsing learns that vampires are real, that he has a natural ability to sense them, and that an agency called Polidorium has been helping his family fight them since 1821.
Emily, whose father is headmaster of a Connecticut boarding school, suffers from nightmares, and when she meets and falls in love with the handsome Del Sugar, pieces of her traumatic past start falling into place.
Mythos Academy student Gwen Frost, who was almost poisoned by the Reapers of Chaos, knows they poisoned someone else, and she must find an antidote for the poison hidden in some ruins.
When sixteen-year-old Thankful Curtis must leave Bright Island, Maine, for the first time in 1937, she has trouble adjusting to life on the mainland, new people, and "proper schooling," and yearns for her days of farming with her father and sailing.
Lindsay wakes up in the Marlwood Academy infirmary to learn that she is possessed by an evil spirit and tried to kill her nemesis Mandy and Mandy's boyfriend Troy and she must rely on an unlikely ally to rid the school of the ghosts that are trying to take over.
When Lindsay Cavanaugh transfers to the prestigious Marlwood Academy after she recovers from a breakdown at her previous high school, she discovers that there is something strange going on that involves a clique and some unsavory activities from the school's little-known past.
Miranda, now a junior, finds her anticipated return to the haunted Bard Academy dampened by the fact that her freshman sister, Lindsay, is attending for the first time, especially when Lindsay falls in with the Parker clique and disappears.
Mythos Academy student Gwen Frost, having been arrested while on her first date with Logan Quinn, is accused of helping the Reapers free Loki from prison and tries to prove her innocence, despite the widely-held belief she is guilty.
Reed and two former Billings Girls, Kiran and Taylor, venture off on a luxurious vacation to the Caribbean, but it quickly becomes evident that exclusive shops and a private island are not enough to keep them out of harm's way.