Ant Man, Wasp and Spider-man catch Enchantress and MODOK in the act of robbing a jewelry store, but during the villains' efforts to escape, Enchantress drops the jewels into the zoo and the squad scrambles to find them all.
Dr. Doom sends his villains into Super Hero City to plant huge vines that will down tear all the buildings, but Wolverine, Spider-Man, and Iceman join with the Incredible Hulk to stop the mutant menace.
When Iron Man tests his newest gadget on the Squaddies, it switches everyone's powers around, but the Squaddies, working as a team, manage to put out a fire after Iron Man gives them a plan.
When three calls for help come in at the same time, it's up to Spider-Man, Thing, Wolverine, Falcon, Storm, and Invisible Woman to team up and tackle triple the trouble!.
After his storm destroys Dr. Strange's magic plants and his hammer breaks the Silver Surfer's wave pool, Thor begins to lose confidence in himself and, when General Ross assigns him to a special mission, questions whether he still has what it takes to be a hero.
A tornado destroys Villainville and Captain America and the rest of the Marvel Super Hero Squad race to help their enemies, but first Captain America must convince Dr. Doom that the Squaddies and the baddies need to work together.