Nancy, helping out with a "chemystery" camp, a special forensics program for high school students, finds herself with a real mystery to solve when the professor who runs the camp suddenly falls into an unexplained coma.
While Nancy and her friends are helping with a high school "chemystery" camp that teaches how science is used to solve crimes, a real mystery involving the professor in charge begins, and Nancy takes over the made-up case and the real one.