Natsume finds himself being blackmailed by a elementary school classmate who knows his secret and says he will expose it if Natsume does not do what he says.
While Natsume and Tanuma are helpng clean up a storehouse of Taki's grandfather's things, the friends accidentally release an angry yokai that all three must work together to get rid of.
To help a kindly yokai read a ruined letter, Natsume needs the assistance of a yokai in the Book of Friends, but getting the help of a yokai his grandmother bound to the book may be difficult.
Takashi Natsume, a high school student with supernatural abilities, begins to make friends at school and agrees to join in a test of courage at an old abandoned high school inhabited by a spirit that has a special hatred for humans.
Natsume's home is attacked by a yokai who claims that Natsume stole her ring when she came to get her name back. Unless he can find the ring in time, he may find himself homeless.
Takashi has to put aside his efforts to free the names his grandmother trapped in her book to join Nyanko in tracking a black Nyanko-sensei look-alike, who stole the Book of Friends, into the woods, where they witness a secret yokai meeting.
Takashi experiences a new challenge when he accidentally releases a yokai the night before the school festival and must get rid of it without Nyanko-sensai backing him.
Takashi investigates when he discovers that a human is attacking yokai and stealing their blood. He finds the case growing increasingly dangerous, however, when his search for information leads him into the occult world of the exorcists.
After Takashi rescues a young boy named Kai from a locked box in an abandoned house, he must discover if Kai, who has been complaining about being chased by ghosts, can see yokai too, or if something else is going on.
Takashi believes he has been able to balance yokai and friends, but finds it difficult to keep spirits and demons at bay while studying with classmates at a country inn.
