Following the death of their parents in an automobile accident, 15-year-old Matthew and his younger, deaf sister run away to Los Angeles where he becomes the only suspect in her brutal beating and murder.
Thirteen-year-old Sammy meets a mysterious man who dies of a heart attack after telling her to get rid of the large amount of money he is carrying, leading her to investigate who the man was and how he came to be carrying so much cash.
Bird, an artistic young African American boy, expresses himself through drawing as he struggles to understand his older brother's drug addiction and death, while a family friend, Uncle Son, provides guidance and understanding.
In their second adventure, the four remaining McNally children are drawn to the mysterious Fishbone Forest in search of their dead brother's stolen brain, only to discover the terrifying Mr. Maggs and his sinister plan to change the world.
Although Little Bill is sad when a friend of the family dies, he remembers the friend's lesson of saying "Merry Christmas" to get people to stop fighting.
Five-year-old Emily tries to understand her grandfather's death by exploring the Christian and Jewish rituals that her family practices during and after his funeral.