It is 2099 and Miguel O'Hara has become the new Spider-Man. Just in time, Spider-Man is rescued from the Public Eye by the mysterious Thanatos, who begins to style himself as a new hero. However, Spider-Man figures the old villain must have something up his sleeve.
Spider-Man is forced to adapt to new situations and tries to learn the identity of the Menace while finding out who is behind the Spider-Tracer killings and anticipating the outcome of the campaign for mayor.
When a boy from Krypton falls to Earth in Metropolis, Superman tries to protect him by fighting Lex Luthor, Bizarro, General Zod, and renegade Kryptonians who trap the Man of Steel in the Phantom Zone.
Barbara Gordon is back as Batgirl and she must stop the nightmare-inducing Mirror from destroying the lives of Gotham citizens while facing her own dark past.
In the wake of Bruce Wayne's passing Dick Grayson takes up the mantle of Batman with Wayne's son Damian as Robin and together they investigate Bruce's mysterious death.