Life is delicious in the town of Chewandswallow where it rains soup and juice, snows mashed potatoes, and blows storms of hamburgers--until the weather takes a turn for the worse.
Larry goes to rescue his friends when they are moved to the Smithsonian, but he and some old and new friends must battle an Egyptian pharaoh and his army of villains for control of the tablet that brings museum exhibits to life.
Kate and Humphrey have been kidnapped and taken to Twin Falls, Idaho. With the help of their friends Marcel and Paddy, they attempt to make it back to Jasper Park before the Eastern pack and Western pack wolves fight.
When Andy grows up, he does not want his toys anymore, so they are sent to a daycare, where they meet other toys and there are lots of kids to play with them, but when things turn bad, they try to escape from the daycare.
In his quest to be the world's greatest villain, Gru plans to steal the Moon, but he meets his greatest challenge when he adopts three little girls to help him on his mission.