When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous plot.
Ten-year-old Zoe Elias, who longs to play the piano but must resign herself to learning the organ, instead, finds that her musicianship has a positive impact on her workaholic mother, her jittery father, and her school social life.
As their auntie's wedding day approaches, the Indian-British Dhillon sisters try to rescue her from her fianc?'s meddling aunt while also competing against one another for the affections of the new, handsome boy at school.
High school sophomore Toby Klein enjoys computer hacking and wearing combat boots, so she thinks it is a joke when she is invited to join the cheerleading squad, but soon she learns cheering is just a cover for an elite group of government operatives.
Fourth-grader Phoebe meets a unicorn named Marigold Heavenly Nostrils which grants her one wish to be best friends. Together Phoebe and Marigold embark on a series of adventures dealing with the ordinary and extraordinary parts of life.