Lizzy hurts the feelings of the not-so-popular Audrey Albright and now she is missing, leading Lizzy to enlist the help of Larry Tudgeman at a science-fiction convention to help her investigate the girl's disappearance.
When Lizzie McGuire takes care of dogs as a fund raising project, someone lets the animals escape from her backyard. She must find the culprit and the animals in order to prevent her project from ending in a disaster.