In war-torn France, Jo McMahon, an Italian-Irish girl from the tenements of Brooklyn, tends to six seriously wounded soldiers in a makeshift medical unit. Enemy bombs have destroyed her hospital convoy, and now Jo singlehandedly struggles to keep her patients and herself alive in a cramped and freezing tent close to German troops. There is a growing tenderness between her and one of her patients, a Scottish officer, but Jo's heart is seared by the pain of all she has lost and seen. She fights to hold on to memories of the past, to the times she shared with her best friend, Kay, whom she met in nursing school. Half a world away in the Pacific, Kay is trapped in a squalid Japanese POW camp in Manila, one of thousands of Allied men, women, and children whose fates rest in the hands of a sadistic enemy. Kay clings to memories in Hawaii, and the handsome flyer who swept her off her feet in the weeks before Pearl Harbor. She also battles to maintain her sanity and save lives as best she can.