Yorick Brown, the last man on Earth, finds himself fighting for survival when he is placed in the care of retired government agent 711 in the backcountry of Colorado while his companions, cloning specialist Dr. Allison Mann and government agent 355, go in search of antibiotics for Brown's monkey Ampersand, the planet's only other living male.
Sixteen-year-old Katniss Everdeen accidentally becomes a contender in the annual Hunger Games, a grave competition hosted by the Capitol where young boys and girls are pitted against one another in a televised fight to the death.
Norbert, thirteen-year-old Alan's diminutive buddy from Jupiter, again takes up residence in Alan's nose to help bail him out when he and best friend Victor get separated from Alan's mother's boyfriend while camping.
While playing a total immersion virtual reality game of kings and intrigue, fourteen-year-old Giannine learns that demonstrators have damaged the equipment to which she is connected, and she must win the game quickly or be damaged herself.
Rett and Bryn, both sixteen, wake in a locked facility, unaware of how they got there, whether they can trust each other, and who or what is with them.
In the distant future, when fifteen-year-old Wren Natsworthy, bored with life in Anchorage, steals an Old-Tech book for a Lost Boy, she sets off a sequence of events that leads her parents, Tom and Hester, back into battle with old enemies and new.
Wetchik, Nafai, and all their family journey to the abandoned spaceport on the planet Harmony to travel to the Earth. Some members of the group are forced to leave against their will, and their anger and hatred will make the journey difficult.