Jonathan and his friends are called to Rome by the emperor in the winter of 80 A.D. to find the new Prometheus believed to have brought an epidemic to the city, but Jonathan, obsessed with reuniting his parents, makes some unwise--and life-threatening--choices.
In 80 A.D., ten-year-old Roman sleuth Flavia and her friends sail from Corinth to Rhodes to try to stop a mysterious man who is kidnapping children and selling them into slavery.
Suspecting their friend Jonathan is alive, Flavia, Nubia, and Lupus go to Rome for the Colosseum Games, facing wild beasts, criminals, conspirators, and gladiators, and where Nubia is called upon to make a terrible choice.
Eleven-year-old Flavia and her friends Jonathan, Lupus, and Nubia are invited to visit Pulchra, who asks them to uncover who is trying to poison her mother.
Flavia and her friends embark on a quest across Mauretania to Volubilis to steal Nero's Eye, a gemstone that bestows the power of rule upon its owner, according to the prophecy of the Delphic Oracle, and they encounter various dangers along the way.
A detective goes missing when the ship carrying Flavia and her friends from North Africa to Ostia is wrecked, and the other detectives take on a quest that brings them to the port of Alexandria where they must decipher codes, travel down the Nile River, and enter tombs to solve the mystery.
Flavia and her friends return to Rome from Ephesus in the year 81, and when they learn about the mysterious death of Emperor Titus, they investigate, leading to many changes for Italia and for themselves.