In the midst of the usual teenaged angst over romantic relationships and figuring out their place in the world, childhood friends Kristin and Daniel reconnect when, in the sixth grade, Daniel is temporarily paralyzed.
Seventeen-year-old Frank Marder struggles to deal with the aftermath of an accident he had while driving drunk that killed two people, including his girlfriend, and left him paralyzed from the neck down.
Dawn Rochelle, a seventeen-year-old girl with leukemia, suffers partial paralysis after three years in remission and, despite her doctors' optimism about her recovery, she wonders how she can find the strength to go on living with her disease.
When her older sister, Marni, is paralyzed jumping off the cliffs into the lake near their house, twelve-year-old Lace feels responsible for the accident and struggles to find a way to help heal her family.
Although tough-talking Harry Sue would like to start a life of crime in order to be "sent up" and find her incarcerated mother, she must first protect the children at her neglectful grandmother's home day care center and befriend a paralyzed boy.
Fourteen-year-old Toby, paralyzed since birth and raised in a convent, suddenly finds himself capable of movement and speech when his long-time companion, a cat, takes him on a magical and mysterious journey to Iceland.