Rookie paramedic Peter Webster begins an intense affair with Sheila, a troubled young woman he pulled from a car wreck, but their love is not enough to keep them together and Peter is raising their daughter alone years later when a phone call from Sheila alters their lives.
The Radleys, an eccentric family of vampires living in the suburbs, struggle but try to deny their natural instincts to avoid eating the neighbors and fit in with their peers.
After losing his wife on September 11, 2001, Gil Castle retreats to his family's isolated Arizona ranch, where he tries to cope with his own grief while learning about the hardships his father and grandfather faced throughout the twentieth century.
Seventeen-year-old Jesse Matson, trying to cope with the fact that his father committed suicide while they were out hunting, begins to question whether the gunshot wound was actually self-afflicted and takes it upon himself to uncover the true nature of the crime.
Twelve-year-old Emma-Rose Paley feels very different from her bubbly parents and thinks only her best friend understands her, but a visit from Emma-Rose's great-aunt from Romania leads her to believe she could be a vampire.