Arthur Conan Doyle and his wife, Louisa, arrive at the Britannic Hotel in 1890s New York, where Louisa, after coming across the body of a woman in the Bowery who she recognizes from the hotel, finds disturbing clues which point back to a stalker.
Scotland Yard Inspector Ian Rutledge is called in to investigate two murders that don't seem to be connected. When a third murder and then a fouth occur, Ian remembers something he witnessed in the war that might give him the key to finding the killer, but it will bring back an episode that Ian has been trying to forget.
Dr. Alex Delaware becomes involved in a case after a woman that had issued a death threat against him is later found dead and her child and sister go missing.
Dexter Morgan feels the murders he commits are justified since he only kills Miami's worst criminals and deviants, but his sense of pride and accomplishment are threatened when a second serial killer arrives, copying Dexter's style and implicating him in more murders.
Anita Blake is called in to investigate a case involving a vampire serial killer who preys on strippers, but as the consort of Master Vampire Jean-Claude, she finds it hard to be totally objective.
