Examines signs and symbols, some of which represent love, hate, happiness, nationality, and religion, and explores how they came to be, what they mean, and what they could mean in the future.
Sam and Dean, brothers who lost their mother to a demonic supernatural force, encounter an angel in a small town in South Dakota on their quest to destroy Lucifer and learn of a secret that could be beneficial to their endeavor.
Sam and Dean are called to San Francisco's Chinatown by renegade angel Castiel who gives them information about a series of killings, and soon they realize they are facing an evil spirit that has been fought by their parents and grandparents in the past.
"Reported sightings of a hellish hound and the discovery of newly dead desiccated corpses bring Sam and Dean Winchester to Brennan, Ohio. But when they catch the monster canine it turns out to be 'Frankenmutt'; a reanimated patchwork of pieces from separate dogs. Soon the brothers are on a trail that leads from mad scientists and biotechnology to a centuries-old alchemist, walking corpses, and an ancient and malevolent power"--Back cover.
Sam and Dean arrive in Clayton Falls, Colorado, after Bobby tells them about reports of strange happenings, but as they investigate a speeding car with no driver, a boy who is attacked by uprooted trees, and a homeless man who claims to have been chased by a giant Gila monster, the Winchesters begin to suspect some nightmares do not end upon awaking.
Sam and Dean arrive in Laurel Hill, New Jersey, and along with Bobby Singer, they investigate a series of accidents and outbreaks that are connected to three teenage boys at the local high school.
When Sam and Dean investigate a truck full of slaughtered illegal Mexican immigrants, Xochi Cazadora, a bandita, guides them into Mexico City and a world of Aztec gods and monsters.
Dean, trying to keep a promise he made to Sam, attempts to lead a normal life with Lisa and Ben, but, after finding out Lucifer could be raised by a spell, he decides to travel to Salem to stop it, while Sam hunts the Salem witches for a different reason.
