Max's destiny to save the world is especially challenging to do when she is faced with her ultimate match, a newer and better version of herself, Maximum Ride II.
Called in to investigate mass fish die-offs and the destruction of ships off the coast of Hawaii, Max and her team are tracked by criminal mastermind Mr. Chu, who has his own plans for the team.
Preparing to defeat a takeover by the mastermind behind the "Re-evolution" genetic engineering plot, Max and her winged Flock companions are torn away from each other and forced into hiding or captivity in order to survive.
Headed for Washington to learn more about their parents and the events leading up to their transformation, the flock realizes their locale is crawling with FBI agents.
Max and her flock escape the school after recovering Angel, who shares what she has learned about their true identities, but Erasers follow them to New York where Max ponders her destiny.
While on a scientific expedition, Max and his friends are targeted by an underworld figure who intends to sell these super-kids to the highest bidder and employs his robot army to collect them.
The flock escaped ITEX and is heading west ready to enjoy some peace and quiet, but Max is more sure than ever that she is meant to save the world, and wonders if this lull is only the calm before the storm.