Three years ago, the melting of arctic permafrost released a pathogen of unknown origin into the atmosphere, causing an event now known as the Hollowing. Those who were impacted slowly became intolerant to normal food, only able to gain sustenance through human flesh. Those who went without flesh quickly became feral, turning on their friends and family. However, scientists were able to create a synthetic version of human meat that would satisfy the hunger of those impacted by the Hollowing. As a result, humanity slowly began to return to normal--albeit with lasting fear and distrust for the people they'd pejoratively dubbed "ghouls." Zoey, Celeste, Valeria, and Jasmine are all ghouls living in Southern California. As a last hurrah before their graduation they decided to attend a musical festival in the desert, armed with a cooler filled with hard seltzers and SynFlesh. But on the first night of the festival, Val goes feral, killing and eating a boy. As other festival guests start disappearing around them, the girls soon discover someone is drugging ghouls and making them feral. If they can't figure out how to stop it, and soon, no one at the festival is safe.