When a lazy bird hatching an egg wants a vacation, she asks Horton, the elephant, to sit on her egg--which he does through all sorts of hazards until he is rewarded for doing what he said he would.
A city of Whos on a speck of dust are threatened with destruction until the smallest Who of all helps convince Horton's friends that Whos really exist.
Poses questions for pondering: "Would you rather be a dog or be a cat?", "Would you rather live in igloos or in tents?", "Would you rather be a mermaid with a tail instead of feet?".