Best friends Randolph, a beaver, and Ivy, a goose, do everything together until Ivy is invited to a girls-only birthday sleepover party and Randolph, full of bad feelings, tries to spoil her fun.
Four students, with their own individual stories, develop a special bond and attract the attention of their teacher, a paraplegic, who chooses them to represent their sixth-grade class in the Academic Bowl competition.
Bee faces friction at home and at school when her widowed father begins seriously dating Jazzi, who seems to take over the house and their lives, but as shared secrets and common interests finally begin to draw them together, Jazzi accidentally makes a terrible mistake.
Sophie does not enjoy energetic, assertive Wendell's weekend visit until the very end, when she learns to assert herself and finds out Wendell can be fun to play with after all.
Devoted to making lists about everything in his life, Wallace the mouse discovers the joys of spontaneity and adventure when he becomes friends with his neighbor Albert.