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In 2407, after the Slow Plague, humanity has ceased to exist--now, "homo factus," the Made Man, has taken over the planet, humans who have through genetic manipulation all but eliminated the imperfections of humanity. Into this world comes Althea-310, who was made to think and feel exactly what her sister Altheas think and feel--and Althea-310 feels she is different from her sisters. After a series of attacks rock their town, Althea-310 finds herself fascinated with Jack, the boy who may be the last genuine human on Earth, who is blamed for the attacks.