Mandy Hope, a girl who helps her parents at the Animal Ark Veterinary Clinic, is shocked to find a very pregnant golden retriever abandoned outside the clinic and determines to find the owner before the puppies arrive.
Mandy and her friend James, assisted by Blackie the labrador retriever, help Mandy's grandmother save the village hospital from being closed and, at the same time, save the lives of a newborn lamb and their young neighbor Jenny.
Adhering to her parents' policy of not permitting wild animals to stay in their veterinary hospital, Mandy finds a "halfway house" for her rescued hedgehogs where they can rehabiltate before returning to the wild.
Twelve-year-old Mandy and her veterinarian parents find themselves involved in the filming of a murder mystery in their village when the canine star of the film runs away.