Wade Wilson, aka the Deadpool, heads into space to take on the galactic assassin Macho Gomez and the Immense Id the Selfish Moon, while back on Earth, his old partners in crime all want a piece of him. He takes on the Hulk, hoping to die, and is locked up in an insane asylum, but his greatest foe turns out to be a version of himself that is composed of his discarded body parts.